Reaction Details Report a problem with these data
Target
Carbonic anhydrase
Ligand
BDBM11638
Substrate
n/a
Meas. Tech.
ChEMBL_1466707 (CHEMBL3404500)
Ki
30±n/a nM
Citation
 Syrjänen, L; Kuuslahti, M; Tolvanen, M; Vullo, D; Parkkila, S; Supuran, CT Theß-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides. Bioorg Med Chem 23:2303-9 (2015) [PubMed]  Article 
Target
Name:
Carbonic anhydrase
Synonyms:
Carbonate dehydratase | Carbonic anhydrase
Type:
PROTEIN
Mol. Mass.:
29919.95
Organism:
Anopheles gambiae
Description:
ChEMBL_109570
Residue:
255
Sequence:
MERILRGVMRYRHTTREQMVQEFRKVRDNPQPKAVFFTCMDSRMIPTRFTETHVGDMFVVRNAGNLVPHAEHFQDEYFSCEPAALELGCVVNNIKHIIVCGHSDCKAMNLLYKLKDPEFASLDNRRISPLRAWLCEHANTSLAKFQNLKEIGLDKPLIFSSETPLRKFVAYIDPENNFAIEDKLSQVNTLQQIENVASYGFLKRRLESHDLHIHALWFDIYTGDIYFFSRNSKRFIAIDESSIDRLLDEVRRYYS
  
Inhibitor
Name:
BDBM11638
Synonyms:
CHEMBL26 | Compound 7 | N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide | SULPIRIDE,(+) | SULPIRIDE,(-) | Sulpiride | Sulpiride, SLP | Sulpiride-R | US10172837, Sulpiride
Type:
Small organic molecule
Emp. Form.:
C15H23N3O4S
Mol. Mass.:
341.426
SMILES:
CCN1CCCC1CNC(=O)c1cc(ccc1OC)S(N)(=O)=O
Structure:
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