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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50077877
Substrate
n/a
Meas. Tech.
ChEMBL_1473395 (CHEMBL3419512)
Ki
5.0±n/a nM
Citation
 Díaz, JL; Christmann, U; Fernández, A; Torrens, A; Port, A; Pascual, R; Álvarez, I; Burgueño, J; Monroy, X; Montero, A; Balada, A; Vela, JM; Almansa, C Synthesis and structure-activity relationship study of a new series of selectives(1) receptor ligands for the treatment of pain: 4-aminotriazoles. J Med Chem 58:2441-51 (2015) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50077877
Synonyms:
CHEMBL3417042 | US9611229, 2
Type:
Small organic molecule
Emp. Form.:
C15H19Cl2N5
Mol. Mass.:
340.251
SMILES:
Clc1ccc(cc1Cl)-n1cc(NCCN2CCCCC2)nn1
Structure:
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