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Target
Transcriptional activator protein LasR
Ligand
BDBM50080868
Substrate
n/a
Meas. Tech.
ChEMBL_1475299 (CHEMBL3425159)
EC50
119±n/a nM
Citation
 O'Brien, KT; Noto, JG; Nichols-O'Neill, L; Perez, LJ Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa. ACS Med Chem Lett 6:162-7 (2015) [PubMed]  Article 
Target
Name:
Transcriptional activator protein LasR
Synonyms:
LASR_PSEAE | lasR
Type:
PROTEIN
Mol. Mass.:
26618.24
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_1475312
Residue:
239
Sequence:
MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAWREHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHGARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSREKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
  
Inhibitor
Name:
BDBM50080868
Synonyms:
CHEMBL3421670
Type:
Small organic molecule
Emp. Form.:
C22H19Br2N3O7
Mol. Mass.:
597.21
SMILES:
[O-][N+](=O)c1ccccc1C(=O)NCc1cc(Br)cc(Br)c1OC(=O)CCCN1C(=O)CCC1=O
Structure:
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