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Target
Neuromedin-K receptor
Ligand
BDBM50081194
Substrate
n/a
Meas. Tech.
ChEMBL_1475774 (CHEMBL3425007)
Ki
4.0±n/a nM
Citation
 Hoveyda, HR; Fraser, GL; Roy, MO; Dutheuil, G; Batt, F; El Bousmaqui, M; Korac, J; Lenoir, F; Lapin, A; Noël, S; Blanc, S Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I). J Med Chem 58:3060-82 (2015) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK-3 receptor | TACR3 | Uncharacterized protein | nk-3
Type:
PROTEIN
Mol. Mass.:
51998.78
Organism:
Macaca mulatta
Description:
ChEMBL_109608
Residue:
463
Sequence:
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGTVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPRANLTNQFVQPSWRIALWSLAYGVVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPTRQSSMYTVTRMESMTVMFDPSDADTARSSRKKRATPRDPSFNGCSRRNSKSASTTSSFISSPYTSVDE
  
Inhibitor
Name:
BDBM50081194
Synonyms:
CHEMBL3422009 | US10544150, Compound 156
Type:
Small organic molecule
Emp. Form.:
C26H19F2N5OS2
Mol. Mass.:
519.589
SMILES:
C[C@H]1N(CCn2c1nnc2-c1csc(n1)-c1ccc(F)cc1F)C(=O)c1ccc(cc1)-c1cccs1 |r|
Structure:
Search PDB for entries with ligand similarity: