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Target
Glycine receptor subunit alpha-1
Ligand
BDBM50030475
Substrate
n/a
Meas. Tech.
ChEMBL_1474520 (CHEMBL3423809)
EC50
400±n/a nM
Citation
 Wells, MM; Tillman, TS; Mowrey, DD; Sun, T; Xu, Y; Tang, P Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptora1 for the treatment of pain. J Med Chem 58:2958-66 (2015) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-1
Synonyms:
GLRA1 | GLRA1_HUMAN | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52635.39
Organism:
Homo sapiens (Human)
Description:
P23415
Residue:
457
Sequence:
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
  
Inhibitor
Name:
BDBM50030475
Synonyms:
7-Dehydrocholesterol | CHEBI:28940 | Cholecalciferol | Colecalciferol | Dihydrocholesterol | Vitamin D | Vitamin D 3
Type:
Small organic molecule
Emp. Form.:
C27H44O
Mol. Mass.:
384.6377
SMILES:
[H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)CCC1=C)[C@H](C)CCCC(C)C |r|
Structure:
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