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Target
D(2) dopamine receptor
Ligand
BDBM50083370
Substrate
n/a
Meas. Tech.
ChEMBL_1474332 (CHEMBL3423552)
Ki
59±n/a nM
Citation
 Zagórska, A; Kolaczkowski, M; Bucki, A; Siwek, A; Kazek, G; Satala, G; Bojarski, AJ; Partyka, A; Wesolowska, A; Pawlowski, M Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity. Eur J Med Chem 97:142-54 (2015) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50083370
Synonyms:
CHEMBL3423340
Type:
Small organic molecule
Emp. Form.:
C25H31Cl2N7O2
Mol. Mass.:
532.465
SMILES:
Cc1cn2c(nc3n(C)c(=O)n(C)c(=O)c23)n1CCCCCN1CCN(CC1)c1ccc(Cl)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: