Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50086124
Substrate
n/a
Meas. Tech.
ChEMBL_1477924 (CHEMBL3429345)
IC50
27000±n/a nM
Citation
 Nepomuceno, GM; Chan, KM; Huynh, V; Martin, KS; Moore, JT; O'Brien, TE; Pollo, LA; Sarabia, FJ; Tadeus, C; Yao, Z; Anderson, DE; Ames, JB; Shaw, JT Synthesis and Evaluation of Quinazolines as Inhibitors of the Bacterial Cell Division Protein FtsZ. ACS Med Chem Lett 6:308-12 (2015) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_ECOLI | ftsZ | sfiB | sulB
Type:
Protein
Mol. Mass.:
40305.83
Organism:
Escherichia coli
Description:
P0A9A6
Residue:
383
Sequence:
MFEPMELTNDAVIKVIGVGGGGGNAVEHMVRERIEGVEFFAVNTDAQALRKTAVGQTIQIGSGITKGLGAGANPEVGRNAADEDRDALRAALEGADMVFIAAGMGGGTGTGAAPVVAEVAKDLGILTVAVVTKPFNFEGKKRMAFAEQGITELSKHVDSLITIPNDKLLKVLGRGISLLDAFGAANDVLKGAVQGIAELITRPGLMNVDFADVRTVMSEMGYAMMGSGVASGEDRAEEAAEMAISSPLLEDIDLSGARGVLVNITAGFDLRLDEFETVGNTIRAFASDNATVVIGTSLDPDMNDELRVTVVATGIGMDKRPEITLVTNKQVQQPVMDRYQQHGMAPLTQEQKPVAKVVNDNAPQTAKEPDYLDIPAFLRKQAD
  
Inhibitor
Name:
BDBM50086124
Synonyms:
CHEMBL3425693
Type:
Small organic molecule
Emp. Form.:
C21H20ClF3N4O2
Mol. Mass.:
452.857
SMILES:
[O-]C(=O)C(F)(F)F.Cc1ccc2nc(\C=C\c3ccc(Cl)cc3)nc(NCC[NH3+])c2c1
Structure:
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