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Target
Voltage-dependent L-type calcium channel subunit alpha-1C
Ligand
BDBM50002338
Substrate
n/a
Meas. Tech.
ChEMBL_1478724 (CHEMBL3430625)
IC50
1300±n/a nM
Citation
 Mirams, GR; Cui, Y; Sher, A; Fink, M; Cooper, J; Heath, BM; McMahon, NC; Gavaghan, DJ; Noble, D Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovasc Res 91:53-61 (2011) [PubMed]  Article 
Target
Name:
Voltage-dependent L-type calcium channel subunit alpha-1C
Synonyms:
CAC1C_CAVPO | CACH2 | CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2
Type:
PROTEIN
Mol. Mass.:
19518.62
Organism:
Cavia porcellus
Description:
ChEMBL_106600
Residue:
169
Sequence:
FQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKRAPESEPSNSTEGETPCGSSFAVFY
  
Inhibitor
Name:
BDBM50002338
Synonyms:
(Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine | 10-(2-(1-methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine | 10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine | 10-[2-(1-Methyl-piperidin-2-yl)-ethyl]-2-methylsulfanyl-10H-phenothiazine (thioridazine) | CHEMBL479 | MELLARIL | MELLARIL-S | THIORIDAZINE | TP-21 | US9504692, Thioridazine
Type:
Small organic molecule
Emp. Form.:
C21H26N2S2
Mol. Mass.:
370.575
SMILES:
CSc1ccc2Sc3ccccc3N(CCC3CCCCN3C)c2c1
Structure:
Search PDB for entries with ligand similarity: