Reaction Details Report a problem with these data
Target
Cytochrome P450 2C8
Ligand
BDBM50363928
Substrate
n/a
Meas. Tech.
ChEMBL_1487039 (CHEMBL3531865)
IC50
5400±n/a nM
Citation
 Foti, RS; Pearson, JT; Wong, SL; Zalikowski, JA; Boudreaux, MD; Prokop, SP; Davis, JA; Banfield, C; Emery, MG; Rock, DA; Wahlstrom, JL; Wienkers, LC; Amore, BM Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors. Drug Metab Dispos 40:2239-49 (2012) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C8
Synonyms:
P450 MP-12/MP-20 | CYPIIC8 | P450 IIC2 | S-mephenytoin 4-hydroxylase | Cytochrome P450 2C8 (CYP2C8) | P450 form 1 | CP2C8_HUMAN | CYP2C8
Type:
Protein
Mol. Mass.:
55839.23
Organism:
Human
Description:
P10632
Residue:
490
Sequence:
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
  
Inhibitor
Name:
BDBM50363928
Synonyms:
CHEMBL1951575
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: