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Target
Sodium/nucleoside cotransporter 1
Ligand
BDBM50088517
Substrate
n/a
Meas. Tech.
ChEMBL_1494515 (CHEMBL3528992)
IC50
5800±n/a nM
Citation
 Lepist, EI; Damaraju, VL; Zhang, J; Gati, WP; Yao, SY; Smith, KM; Karpinski, E; Young, JD; Leung, KH; Cass, CE Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1. Drug Metab Dispos 41:916-22 (2013) [PubMed]  Article 
Target
Name:
Sodium/nucleoside cotransporter 1
Synonyms:
CNT1 | S28A1_HUMAN | SLC28A1
Type:
PROTEIN
Mol. Mass.:
71589.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1494515
Residue:
649
Sequence:
MENDPSRRRESISLTPVAKGLENMGADFLESLEEGQLPRSDLSPAEIRSSWSEAAPKPFSRWRNLQPALRARSFCREHMQLFRWIGTGLLCTGLSAFLLVACLLDFQRALALFVLTCVVLTFLGHRLLKRLLGPKLRRFLKPQGHPRLLLWFKRGLALAAFLGLVLWLSLDTSQRPEQLVSFAGICVFVALLFACSKHHCAVSWRAVSWGLGLQFVLGLLVIRTEPGFIAFEWLGEQIRIFLSYTKAGSSFVFGEALVKDVFAFQVLPIIVFFSCVISVLYHVGLMQWVILKIAWLMQVTMGTTATETLSVAGNIFVSQTEAPLLIRPYLADMTLSEVHVVMTGGYATIAGSLLGAYISFGIDATSLIAASVMAAPCALALSKLVYPEVEESKFRREEGVKLTYGDAQNLIEAASTGAAISVKVVANIAANLIAFLAVLDFINAALSWLGDMVDIQGLSFQLICSYILRPVAFLMGVAWEDCPVVAELLGIKLFLNEFVAYQDLSKYKQRRLAGAEEWVGDRKQWISVRAEVLTTFALCGFANFSSIGIMLGGLTSMVPQRKSDFSQIVLRALFTGACVSLVNACMAGILYMPRGAEVDCMSLLNTTLSSSSFEIYQCCREAFQSVNPEFSPEALDNCCRFYNHTICAQ
  
Inhibitor
Name:
BDBM50088517
Synonyms:
CHEBI:16704 | Uridine
Type:
Small organic molecule
Emp. Form.:
C9H12N2O6
Mol. Mass.:
244.2014
SMILES:
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(=O)[nH]c1=O |r|
Structure:
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