Reaction Details Report a problem with these data
Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50089449
Substrate
n/a
Meas. Tech.
ChEMBL_1496953 (CHEMBL3579427)
Ki
30±n/a nM
Citation
 Eng, WS; Hocková, D; ?pacek, P; Janeba, Z; West, NP; Woods, K; Naesens, LM; Keough, DT; Guddat, LW First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity. J Med Chem 58:4822-38 (2015) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50089449
Synonyms:
CHEMBL3578114
Type:
Small organic molecule
Emp. Form.:
C15H30N7O10P3
Mol. Mass.:
561.3609
SMILES:
Nc1nc2n(CCN(CCN(CCP(O)(O)=O)CCP(O)(O)=O)CCP(O)(O)=O)cnc2c(=O)[nH]1
Structure:
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