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Target
Monocarboxylate transporter 1
Ligand
BDBM50092069
Substrate
n/a
Meas. Tech.
ChEMBL_1498543 (CHEMBL3584796)
IC50
8.0±n/a nM
Citation
 Gurrapu, S; Jonnalagadda, SK; Alam, MA; Nelson, GL; Sneve, MG; Drewes, LR; Mereddy, VR Monocarboxylate transporter 1 inhibitors as potential anticancer agents. ACS Med Chem Lett 6:558-61 (2015) [PubMed]  Article 
Target
Name:
Monocarboxylate transporter 1
Synonyms:
MCT 1 | MOT1_RAT | Mct1 | Monocarboxylate transporter 1 | Monocarboxylate transporter 1 (MCT1) | Slc16a1 | Solute carrier family 16 member 1
Type:
Enzyme
Mol. Mass.:
53245.17
Organism:
Rattus norvegicus (Rat)
Description:
P53987
Residue:
494
Sequence:
MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQTVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPLQNSSGDPAEEESPV
  
Inhibitor
Name:
BDBM50092069
Synonyms:
CHEMBL3582422 | US9296728, 20
Type:
Small organic molecule
Emp. Form.:
C23H18N2O3
Mol. Mass.:
370.4006
SMILES:
COc1cc(ccc1\C=C(/C#N)C(O)=O)N(c1ccccc1)c1ccccc1
Structure:
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