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Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50094223
Substrate
n/a
Meas. Tech.
ChEMBL_1500300 (CHEMBL3588724)
IC50
0.230000±n/a nM
Citation
 Takahashi, B; Funami, H; Iwaki, T; Maruoka, H; Nagahira, A; Koyama, M; Kamiide, Y; Matsuo, T; Muto, T; Annoura, H 2-Aminoalkyl nicotinamide derivatives as pure inverse agonists of the ghrelin receptor. Bioorg Med Chem Lett 25:2707-12 (2015) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50094223
Synonyms:
CHEMBL3586033
Type:
Small organic molecule
Emp. Form.:
C34H38N4O4
Mol. Mass.:
566.6899
SMILES:
[H][C@@]12CC[C@@]([H])(C=C(C1)c1cnc(NCc3ccc4CCOc4c3)c(c1)C(=O)NC[C@H]1COc3ccccc3O1)N2C(C)C |r,c:6|
Structure:
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