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Target
Ghrelin O-acyltransferase
Ligand
BDBM50094877
Substrate
n/a
Meas. Tech.
ChEMBL_1502747 (CHEMBL3590857)
IC50
6000±n/a nM
Citation
 Zhao, F; Darling, JE; Gibbs, RA; Hougland, JL A new class of ghrelin O-acyltransferase inhibitors incorporating triazole-linked lipid mimetic groups. Bioorg Med Chem Lett 25:2800-3 (2015) [PubMed]  Article 
Target
Name:
Ghrelin O-acyltransferase
Synonyms:
GOAT | Ghrelin O-acyltransferase (GOAT) | MBOA4_HUMAN | MBOAT4 | Membrane-bound O-acyltransferase domain-containing protein 4 | O-acyltransferase domain-containing protein 4 | OACT4
Type:
Enzyme
Mol. Mass.:
49733.10
Organism:
Homo sapiens (Human)
Description:
Q96T53
Residue:
435
Sequence:
MEWLWLFFLHPISFYQGAAFPFALLFNYLCIMDSFSTRARYLFLLTGGGALAVAAMGSYAVLVFTPAVCAVALLCSLAPQQVHRWTFCFQMSWQTLCHLGLHYTEYYLHEPPSVRFCITLSSLMLLTQRVTSLSLDICEGKVKAASGGFRSRSSLSEHVCKALPYFSYLLFFPALLGGSLCSFQRFQARVQGSSALHPRHSFWALSWRGLQILGLECLNVAVSRVVDAGAGLTDCQQFECIYVVWTTAGLFKLTYYSHWILDDSLLHAAGFGPELGQSPGEEGYVPDADIWTLERTHRISVFSRKWNQSTARWLRRLVFQHSRAWPLLQTFAFSAWWHGLHPGQVFGFVCWAVMVEADYLIHSFANEFIRSWPMRLFYRTLTWAHTQLIIAYIMLAVEVRSLSSLWLLCNSYNSVFPMVYCILLLLLAKRKHKCN
  
Inhibitor
Name:
BDBM50094877
Synonyms:
CHEMBL3589128
Type:
Small organic molecule
Emp. Form.:
C32H43N9O6
Mol. Mass.:
649.7405
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cn1cc(Cc2ccccc2)nn1)NC(=O)[C@H](CO)NC(=O)CN)C(N)=O |r|
Structure:
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