Reaction Details Report a problem with these data
Target
Growth/differentiation factor 8
Ligand
BDBM50095122
Substrate
n/a
Meas. Tech.
ChEMBL_1503690 (CHEMBL3592251)
IC50
47920±n/a nM
Citation
 Zhu, J; Mishra, RK; Schiltz, GE; Makanji, Y; Scheidt, KA; Mazar, AP; Woodruff, TK Virtual High-Throughput Screening To Identify Novel Activin Antagonists. J Med Chem 58:5637-48 (2015) [PubMed]  Article 
Target
Name:
Growth/differentiation factor 8
Synonyms:
GDF-8 | GDF8_MOUSE | Gdf8 | Growth/differentiation factor 8 | Mstn | Myostatin
Type:
PROTEIN
Mol. Mass.:
42922.91
Organism:
Mus musculus
Description:
ChEMBL_109825
Residue:
376
Sequence:
MMQKLQMYVYIYLFMLIAAGPVDLNEGSEREENVEKEGLCNACAWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
  
Inhibitor
Name:
BDBM50095122
Synonyms:
CHEMBL3589518
Type:
Small organic molecule
Emp. Form.:
C25H25N5O3
Mol. Mass.:
443.4977
SMILES:
CCn1c(nc2cc(NC(=O)COC)cc(C(=O)NCc3ccccc3)c12)-c1cccnc1
Structure:
Search PDB for entries with ligand similarity: