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Target
Serine/threonine-protein kinase PAK 4
Ligand
BDBM101618
Substrate
n/a
Meas. Tech.
ChEMBL_1499595 (CHEMBL3584541)
Ki
15±n/a nM
Citation
 Crawford, JJ; Lee, W; Aliagas, I; Mathieu, S; Hoeflich, KP; Zhou, W; Wang, W; Rouge, L; Murray, L; La, H; Liu, N; Fan, PW; Cheong, J; Heise, CE; Ramaswamy, S; Mintzer, R; Liu, Y; Chao, Q; Rudolph, J Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors. J Med Chem 58:5121-36 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase PAK 4
Synonyms:
KIAA1142 | PAK4 | PAK4_HUMAN | p21-Activated kinase 4 (PAK4)
Type:
Protein
Mol. Mass.:
64098.01
Organism:
Homo sapiens (Human)
Description:
O96013
Residue:
591
Sequence:
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
  
Inhibitor
Name:
BDBM101618
Synonyms:
US8530652, 114
Type:
Small organic molecule
Emp. Form.:
C25H30N8OS
Mol. Mass.:
490.624
SMILES:
CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)n[nH]c2C1(C)C)c1ccccc1
Structure:
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