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Target
Bromodomain-containing protein 9
Ligand
BDBM50098305
Substrate
n/a
Meas. Tech.
ChEMBL_1502834 (CHEMBL3591394)
Kd
1259±n/a nM
Citation
 Bamborough, P; Chung, CW; Furze, RC; Grandi, P; Michon, AM; Sheppard, RJ; Barnett, H; Diallo, H; Dixon, DP; Douault, C; Jones, EJ; Karamshi, B; Mitchell, DJ; Prinjha, RK; Rau, C; Watson, RJ; Werner, T; Demont, EH Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors. J Med Chem 58:6151-78 (2015) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 9
Synonyms:
BRD9 | BRD9_HUMAN | Bromodomain-containing protein 9 | Rhabdomyosarcoma antigen MU-RMS-40.8
Type:
PROTEIN
Mol. Mass.:
66994.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108000
Residue:
597
Sequence:
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLGDSSSSVLEFMSMKSYPDVSVDISMLSSLGKVKKELDPDDSHLNLDETTKLLQDLHEAQAERGGSRPSSNLSSLSNASERDQHHLGSPSRLSVGEQPDVTHDPYEFLQSPEPAASAKT
  
Inhibitor
Name:
BDBM50098305
Synonyms:
CHEMBL3590405
Type:
Small organic molecule
Emp. Form.:
C27H34N4O4S
Mol. Mass.:
510.648
SMILES:
Cc1cncc(c1)-c1ccc(N[C@@H]2CCNC[C@H]2OCC2CCS(=O)(=O)CC2)c2[nH]c(=O)c(C)cc12 |r|
Structure:
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