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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50106158
Substrate
n/a
Meas. Tech.
ChEMBL_1506411 (CHEMBL3599707)
EC50
400±n/a nM
Citation
 Han, S; Narayanan, S; Kim, SH; Calderon, I; Zhu, X; Kawasaki, A; Yue, D; Lehmann, J; Wong, A; Buzard, DJ; Semple, G; Carroll, C; Chu, ZL; Al-Sharmma, H; Shu, HH; Tung, SF; Unett, DJ; Behan, DP; Yoon, WH; Morgan, M; Usmani, KA; Chen, C; Sadeque, A; Leonard, JN; Jones, RM Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series. Bioorg Med Chem Lett 25:3034-8 (2015) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
GP119_RAT | Gpr119
Type:
PROTEIN
Mol. Mass.:
51687.59
Organism:
Rattus norvegicus
Description:
ChEMBL_1506411
Residue:
468
Sequence:
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLADGSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG
  
Inhibitor
Name:
BDBM50106158
Synonyms:
CHEMBL3598089
Type:
Small organic molecule
Emp. Form.:
C25H39N3O5
Mol. Mass.:
461.5943
SMILES:
CN(C)C(=O)c1ccc(O[C@H]2CC[C@@H](CC2)OC2CCN(CC2)C(=O)OC(C)(C)C)nc1C |r,wU:10.9,wD:13.16,(9.05,3.72,;7.99,3.1,;6.92,3.71,;8,1.56,;9.07,.95,;6.67,.78,;5.33,1.55,;4,.77,;4,-.77,;2.67,-1.54,;1.33,-.77,;,-1.54,;-1.33,-.77,;-1.33,.77,;,1.54,;1.33,.77,;-2.67,1.54,;-2.66,3.08,;-4,3.86,;-3.99,5.4,;-2.65,6.16,;-1.32,5.39,;-1.33,3.85,;-2.65,7.7,;-3.71,8.33,;-1.31,8.47,;-1.3,10.01,;-.23,10.62,;-1.29,11.24,;-2.36,10.63,;5.34,-1.53,;6.67,-.76,;7.74,-1.37,)|
Structure:
Search PDB for entries with ligand similarity: