Reaction Details Report a problem with these data
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Ligand
BDBM50106877
Substrate
n/a
Meas. Tech.
ChEMBL_1508767 (CHEMBL3603106)
IC50
>100000±n/a nM
Citation
 Zang, W; Hao, Y; Wang, Z; Zheng, W Novel thiourea-based sirtuin inhibitory warheads. Bioorg Med Chem Lett 25:3319-24 (2015) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Synonyms:
NAD-dependent protein deacetylase sirtuin-5 (SIRT5) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | Regulatory protein SIR2 homolog 5 | SIR2-like protein 5 | SIR2L5 | SIR5_HUMAN | SIRT5
Type:
Protein
Mol. Mass.:
33892.62
Organism:
Homo sapiens (Human)
Description:
Q9NXA8
Residue:
310
Sequence:
MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
  
Inhibitor
Name:
BDBM50106877
Synonyms:
CHEMBL3601371
Type:
Small organic molecule
Emp. Form.:
C30H54N8O8S
Mol. Mass.:
686.864
SMILES:
CCOC(=O)CCNC(=S)NCCCC[C@H](NC(=O)[C@H](CCCCNC(C)=O)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)=O)C(N)=O |r|
Structure:
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