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Target
Transthyretin
Ligand
BDBM50109016
Substrate
n/a
Meas. Tech.
ChEMBL_1508576 (CHEMBL3602659)
IC50
170000±n/a nM
Citation
 Iakovleva, I; Brännström, K; Nilsson, L; Gharibyan, AL; Begum, A; Anan, I; Walfridsson, M; Sauer-Eriksson, AE; Olofsson, A Enthalpic Forces Correlate with the Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma. J Med Chem 58:6507-15 (2015) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50109016
Synonyms:
Aceclofenac | CHEBI:31159
Type:
Small organic molecule
Emp. Form.:
C16H13Cl2NO4
Mol. Mass.:
354.185
SMILES:
OC(=O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Structure:
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