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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50111602
Substrate
n/a
Meas. Tech.
ChEMBL_1510458 (CHEMBL3607383)
IC50
20±n/a nM
Citation
 Wang, Y; Yang, T; Liu, Q; Ma, Y; Yang, L; Zhou, L; Xiang, Z; Cheng, Z; Lu, S; Orband-Miller, LA; Zhang, W; Wu, Q; Zhang, K; Li, Y; Xiang, JN; Elliott, JD; Leung, S; Ren, F; Lin, X Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent ROR¿t inverse agonists. Bioorg Med Chem 23:5293-302 (2015) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50111602
Synonyms:
CHEMBL3605085
Type:
Small organic molecule
Emp. Form.:
C26H21F3N2O4S2
Mol. Mass.:
546.581
SMILES:
CCS(=O)(=O)c1ccc(CC(=O)Nc2nc(c(Oc3ccc(cc3)C(F)(F)F)s2)-c2ccccc2)cc1
Structure:
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