Reaction Details Report a problem with these data
Target
Amiloride-sensitive sodium channel subunit alpha
Ligand
BDBM50112168
Substrate
n/a
Meas. Tech.
ChEMBL_1512947 (CHEMBL3609986)
IC50
70±n/a nM
Citation
 Blass, B Novel Pyrazine Amide Compounds. ACS Med Chem Lett 6:729-31 (2015) [PubMed]  Article 
Target
Name:
Amiloride-sensitive sodium channel subunit alpha
Synonyms:
Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel subunit alpha | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNNA_MOUSE | Scnn1a
Type:
PROTEIN
Mol. Mass.:
78903.70
Organism:
Mus musculus
Description:
ChEMBL_109863
Residue:
699
Sequence:
MLDHTRAPELNLDLDLDVSNSPKGSMKGNNFKEQDLCPPLPMQGLGKGDKREEQALGPEPSEPRQPTEEEEALIEFHRSYRELFQFFCNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYFSYPVSLNINLNSDKLVFPAVTVCTLNPYRYTEIKEDLEELDRITEQTLFDLYKYNSSYTRQAGGRRRSTRDLRGALPHPLQRLRTPPPPNPARSARSASSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPDTSPALEEEALGSFIFTCRFNQAPCNQANYSQFHHPMYGNCYTFNNKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVMVHGQDEPAFMDDGGFNVRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQENMIKKCGCAYIFYPKPKGVEFCDYLKQSSWGYCYYKLQAAFSLDSLGCFSKCRKPCSVTNYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTMVSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLIMLLHRFRSRYWSPGRGARGAREVASTPASSFPSRFCPHPTSPPPSLPQQGTTPPLALTAPPPAYATLGPSASPLDSAVPGSSACAPAMAL
  
Inhibitor
Name:
BDBM50112168
Synonyms:
CHEMBL3608423
Type:
Small organic molecule
Emp. Form.:
C21H30Cl2N6O2
Mol. Mass.:
469.408
SMILES:
[Cl-].COc1ccc(CCC[N@@+]2(C)CCC[C@@H](C2)NC(=O)c2nc(Cl)c(N)nc2N)cc1 |r|
Structure:
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