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Target
Cathepsin S
Ligand
BDBM50114024
Substrate
n/a
Meas. Tech.
ChEMBL_1510852 (CHEMBL3606688)
Ki
5000±n/a nM
Citation
 Bori?ek, J; Vizovi?ek, M; Sosnowski, P; Turk, B; Turk, D; Mohar, B; Novic, M Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J Med Chem 58:6928-37 (2015) [PubMed]  Article 
Target
Name:
Cathepsin S
Synonyms:
CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein
Type:
Protein
Mol. Mass.:
37507.38
Organism:
Homo sapiens (Human)
Description:
P25774
Residue:
331
Sequence:
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
  
Inhibitor
Name:
BDBM50114024
Synonyms:
CHEMBL3605413
Type:
Small organic molecule
Emp. Form.:
C16H19FN4O2
Mol. Mass.:
318.3461
SMILES:
Nc1ccc(cc1F)C(=O)NC1(CCCCC1)C(=O)NCC#N
Structure:
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