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Target
Cathepsin K
Ligand
BDBM50114024
Substrate
n/a
Meas. Tech.
ChEMBL_1510849 (CHEMBL3606685)
Ki
22±n/a nM
Citation
 Bori?ek, J; Vizovi?ek, M; Sosnowski, P; Turk, B; Turk, D; Mohar, B; Novic, M Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J Med Chem 58:6928-37 (2015) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50114024
Synonyms:
CHEMBL3605413
Type:
Small organic molecule
Emp. Form.:
C16H19FN4O2
Mol. Mass.:
318.3461
SMILES:
Nc1ccc(cc1F)C(=O)NC1(CCCCC1)C(=O)NCC#N
Structure:
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