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Target
Procathepsin L
Ligand
BDBM50114024
Substrate
n/a
Meas. Tech.
ChEMBL_1510850 (CHEMBL3606686)
Ki
720±n/a nM
Citation
 Bori?ek, J; Vizovi?ek, M; Sosnowski, P; Turk, B; Turk, D; Mohar, B; Novic, M Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J Med Chem 58:6928-37 (2015) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50114024
Synonyms:
CHEMBL3605413
Type:
Small organic molecule
Emp. Form.:
C16H19FN4O2
Mol. Mass.:
318.3461
SMILES:
Nc1ccc(cc1F)C(=O)NC1(CCCCC1)C(=O)NCC#N
Structure:
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