Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50116358
Substrate
n/a
Meas. Tech.
ChEMBL_1511506 (CHEMBL3606855)
Ki
298±n/a nM
Citation
 Evans, GB; Cameron, SA; Luxenburger, A; Guan, R; Suarez, J; Thomas, K; Schramm, VL; Tyler, PC Tight binding enantiomers of pre-clinical drug candidates. Bioorg Med Chem 23:5326-33 (2015) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Purine Nucleoside Phosphorylase (PNP) | pfPNP
Type:
Enzyme
Mol. Mass.:
26857.85
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
245
Sequence:
MDNLLRHLKISKEQITPVVLVVGDPGRVDKIKVVCDSYVDLAYNREYKSVECHYKGQKFLCVSHGVGSAGCAVCFEELCQNGAKVIIRAGSCGSLQPDLIKRGDICICNAAVREDRVSHLLIHGDFPAVGDFDVYDTLNKCAQELNVPVFNGISVSSDMYYPNKIIPSRLEDYSKANAAVVEMELATLMVIGTLRKVKTGGILIVDGCPFKWDEGDFDNNLVPHQLENMIKIALGACAKLATKYA
  
Inhibitor
Name:
BDBM50116358
Synonyms:
CHEMBL3604359
Type:
Small organic molecule
Emp. Form.:
C13H18N4O2S
Mol. Mass.:
294.373
SMILES:
CSC[C@@H]1CN(Cc2c[nH]c3c(O)ncnc23)C[C@H]1O |r|
Structure:
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