Reaction Details Report a problem with these data
Target
Caspase-6
Ligand
BDBM50117679
Substrate
n/a
Meas. Tech.
ChEMBL_1515213 (CHEMBL3614560)
Kd
2900±n/a nM
Citation
 Pollock, J; Borkin, D; Lund, G; Purohit, T; Dyguda-Kazimierowicz, E; Grembecka, J; Cierpicki, T Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J Med Chem 58:7465-74 (2015) [PubMed]  Article 
Target
Name:
Caspase-6
Synonyms:
Apoptotic protease Mch-2 | CASP-6 | CASP6 | CASP6_HUMAN | Caspase | MCH2
Type:
Enzyme
Mol. Mass.:
33312.62
Organism:
Homo sapiens (Human)
Description:
P55212
Residue:
293
Sequence:
MSSASGLRRGHPAGGEENMTETDAFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN
  
Inhibitor
Name:
BDBM50117679
Synonyms:
CHEMBL3613793
Type:
Small organic molecule
Emp. Form.:
C16H14N4O
Mol. Mass.:
278.3086
SMILES:
Oc1ccccc1CNc1ncccc1-c1ncccn1
Structure:
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