Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50118208
Substrate
n/a
Meas. Tech.
ChEMBL_1514780 (CHEMBL3615102)
Ki
3.7±n/a nM
Citation
 Rankin, GM; Vullo, D; Supuran, CT; Poulsen, SA Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases. J Med Chem 58:7580-90 (2015) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50118208
Synonyms:
CHEMBL3613283
Type:
Small organic molecule
Emp. Form.:
C27H29N4O13PS
Mol. Mass.:
680.577
SMILES:
CC(=O)O[C@@H]1[C@@H](COP2(=O)OCc3ccccc3O2)O[C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)n1cc(nn1)-c1ccc(cc1)S(N)(=O)=O |r|
Structure:
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