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Target
Poly(A)-specific ribonuclease PARN
Ligand
BDBM50119654
Substrate
n/a
Meas. Tech.
ChEMBL_1518115 (CHEMBL3619398)
IC50
119000±n/a nM
Citation
Jadhav, GP; Kaur, I; Maryati, M; Airhihen, B; Fischer, PM; Winkler, GS Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1. Bioorg Med Chem Lett 25:4219-24 (2015) [PubMed] Article
More Info.:
Target
Name:
Poly(A)-specific ribonuclease PARN
Synonyms:
DAN | PARN | PARN_HUMAN | Poly(A)-specific ribonuclease (PARN) | Polyadenylate-specific ribonuclease
Type:
Enzyme
Mol. Mass.:
73446.57
Organism:
Homo sapiens (Human)
Description:
O95453
Residue:
639
Sequence:
MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW