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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50120914
Substrate
n/a
Meas. Tech.
ChEMBL_1520751 (CHEMBL3625774)
IC50
60±n/a nM
Citation
 Lloyd, J; Finlay, HJ; Kover, A; Johnson, J; Pi, Z; Jiang, J; Neels, J; Cavallaro, C; Wexler, R; Conder, ML; Shi, H; Li, D; Sun, H; Chimalakonda, A; Huang, C; Salvati, M; Levesque, P Pseudosaccharin amines as potent and selective KV1.5 blockers. Bioorg Med Chem Lett 25:4983-6 (2015) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50120914
Synonyms:
CHEMBL3622362
Type:
Small organic molecule
Emp. Form.:
C23H29N3O5S2
Mol. Mass.:
491.623
SMILES:
CCS(=O)(=O)N[C@H]1CC[C@@](CNC2=NS(=O)(=O)c3cccc(OC)c23)(CC1)c1ccccc1 |r,wU:6.5,9.9,t:12,(1.02,11.67,;.63,10.5,;1.66,9.35,;2.87,9.6,;2.48,8.44,;1.18,7.89,;2.2,6.74,;3.71,7.06,;4.74,5.91,;4.23,4.48,;3.75,3.01,;2.24,2.7,;1.76,1.24,;2.66,.02,;1.76,-1.24,;.93,-2.14,;2.97,-1.47,;.3,-.77,;-1.03,-1.55,;-2.38,-.77,;-2.38,.77,;-1.03,1.55,;-1.02,3.09,;-2.09,3.71,;.3,.77,;2.75,4.13,;1.72,5.28,;5.74,4.79,;6.76,3.65,;8.27,3.96,;8.75,5.43,;7.72,6.57,;6.22,6.26,)|
Structure:
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