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Target
Potassium voltage-gated channel subfamily E/KQT member 1
Ligand
BDBM50121051
Substrate
n/a
Meas. Tech.
ChEMBL_1520988 (CHEMBL3624292)
EC50
>100000±n/a nM
Citation
 Davoren, JE; Claffey, MM; Snow, SL; Reese, MR; Arora, G; Butler, CR; Boscoe, BP; Chenard, L; DeNinno, SL; Drozda, SE; Duplantier, AJ; Moine, L; Rogers, BN; Rong, S; Schuyten, K; Wright, AS; Zhang, L; Serpa, KA; Weber, ML; Stolyar, P; Whisman, TL; Baker, K; Tse, K; Clark, AJ; Rong, H; Mather, RJ; Lowe, JA Discovery of a novel Kv7 channel opener as a treatment for epilepsy. Bioorg Med Chem Lett 25:4941-4 (2015) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily E/KQT member 1
Synonyms:
Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1 | Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK)
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 158552
Components:
This complex has 2 components.
Component 1
Name:
Potassium voltage-gated channel subfamily E member 1
Synonyms:
Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | KCNE1_HUMAN | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel beta subunit Mink | Voltage-gated potassium channel, IKs
Type:
PROTEIN
Mol. Mass.:
14676.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456351
Residue:
129
Sequence:
MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNTHLPETKPSP
  
Component 2
Name:
Potassium voltage-gated channel subfamily KQT member 1
Synonyms:
KCNA8 | KCNA9 | KCNQ (Kv7) potassium channel | KCNQ1 | KCNQ1_HUMAN | KVLQT1 | Voltage-gated potassium channel subunit Kv7.1 | Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1
Type:
PROTEIN
Mol. Mass.:
74739.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1454245
Residue:
676
Sequence:
MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPGPAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLPTYEQLTVPRRGPDEGS
  
Inhibitor
Name:
BDBM50121051
Synonyms:
CHEMBL3621437
Type:
Small organic molecule
Emp. Form.:
C18H30N4O4
Mol. Mass.:
366.4552
SMILES:
COC1CCN(CC1)c1nc(OC)c(NC(=O)CC(C)(C)C)c(OC)n1
Structure:
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