Reaction Details Report a problem with these data
Target
Deoxyribonuclease-1
Ligand
BDBM50121752
Substrate
n/a
Meas. Tech.
ChEMBL_1516649 (CHEMBL3620429)
IC50
>100000±n/a nM
Citation
 Chapman, TM; Gillen, KJ; Wallace, C; Lee, MT; Bakrania, P; Khurana, P; Coombs, PJ; Stennett, L; Fox, S; Bureau, EA; Brownlees, J; Melton, DW; Saxty, B Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF. Bioorg Med Chem Lett 25:4097-103 (2015) [PubMed]  Article 
Target
Name:
Deoxyribonuclease-1
Synonyms:
DNAS1_HUMAN | DNASE1 | DNL1 | DNL1 | DNase I | DRNI | Deoxyribonuclease I | Deoxyribonuclease-1 | INN=Dornase alfa
Type:
PROTEIN
Mol. Mass.:
31422.78
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109543
Residue:
282
Sequence:
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
  
Inhibitor
Name:
BDBM50121752
Synonyms:
CHEMBL3617028
Type:
Small organic molecule
Emp. Form.:
C16H15Br2N3O3
Mol. Mass.:
457.117
SMILES:
Cc1cccc(NCC(=O)N\N=C\c2cc(Br)c(O)c(O)c2Br)c1
Structure:
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