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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50122756
Substrate
n/a
Meas. Tech.
ChEMBL_1520114 (CHEMBL3625578)
EC50
3.8±n/a nM
Citation
 Liu, P; Hu, Z; DuBois, BG; Moyes, CR; Hunter, DN; Zhu, C; Kar, NF; Zhu, Y; Garfunkle, J; Kang, L; Chicchi, G; Ehrhardt, A; Woods, A; Seo, T; Woods, M; van Heek, M; Dingley, KH; Pang, J; Salituro, GM; Powell, J; Terebetski, JL; Hornak, V; Campeau, LC; Lamberson, J; Ujjainwalla, F; Miller, M; Stamford, A; Wood, HB; Kowalski, T; Nargund, RP; Edmondson, SD Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes. ACS Med Chem Lett 6:936-41 (2015) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
GP119_MOUSE | Gpr119
Type:
PROTEIN
Mol. Mass.:
37009.07
Organism:
Mus musculus
Description:
ChEMBL_1506420
Residue:
335
Sequence:
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
  
Inhibitor
Name:
BDBM50122756
Synonyms:
CHEMBL3622179
Type:
Small organic molecule
Emp. Form.:
C23H28FN7O2
Mol. Mass.:
453.5125
SMILES:
COCc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1COCc1ccc(c(F)c1)-n1cnnn1 |r|
Structure:
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