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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM50129862
Substrate
n/a
Meas. Tech.
ChEMBL_1524132 (CHEMBL3631217)
IC50
190±n/a nM
Citation
 Giraud, F; Bourhis, M; Ebrahimi, E; Herfindal, L; Choudhury, RR; Bjørnstad, R; Døskeland, SO; Anizon, F; Moreau, P Synthesis and activities of new indolopyrrolobenzodiazepine derivatives toward acute myeloid leukemia cells. Bioorg Med Chem 23:7313-23 (2015) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50129862
Synonyms:
CHEMBL3629383
Type:
Small organic molecule
Emp. Form.:
C20H15N3O2
Mol. Mass.:
329.352
SMILES:
O=Cc1cn2CC(Cn3c4ccccc4c4ccc1c2c34)OCC#N
Structure:
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