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Target
Sodium channel protein type 1 subunit alpha [1489-1708]
Ligand
BDBM50130535
Substrate
n/a
Meas. Tech.
ChEMBL_1525517 (CHEMBL3636870)
IC50
670±n/a nM
Citation
 Suzuki, S; Kuroda, T; Kimoto, H; Domon, Y; Kubota, K; Kitano, Y; Yokoyama, T; Shimizugawa, A; Sugita, R; Koishi, R; Asano, D; Tamaki, K; Shinozuka, T; Kobayashi, H Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors. Bioorg Med Chem Lett 25:5419-23 (2015) [PubMed]  Article 
Target
Name:
Sodium channel protein type 1 subunit alpha [1489-1708]
Synonyms:
SCN1A_MOUSE | Scn1a | Voltage-gated sodium channel alpha subunit Nav1.1
Type:
PROTEIN
Mol. Mass.:
25514.04
Organism:
Mus musculus
Description:
ChEMBL_109872
Residue:
220
Sequence:
QKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFE
  
Inhibitor
Name:
BDBM50130535
Synonyms:
CHEMBL3632695
Type:
Small organic molecule
Emp. Form.:
C29H33F3N2O8
Mol. Mass.:
594.5761
SMILES:
OC(=O)\C=C\C(O)=O.COc1cc(ccc1COCC(O)CN1CCC(CC1)N1Cc2ccccc2C1=O)C(F)(F)F
Structure:
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