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Target
Protein arginine N-methyltransferase 1 [11-371]
Ligand
BDBM50130931
Substrate
n/a
Meas. Tech.
ChEMBL_1525938 (CHEMBL3635610)
IC50
13000±n/a nM
Citation
 Yu, XR; Tang, Y; Wang, WJ; Ji, S; Ma, S; Zhong, L; Zhang, CH; Yang, J; Wu, XA; Fu, ZY; Li, LL; Yang, SY Discovery and structure-activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors. Bioorg Med Chem Lett 25:5449-53 (2015) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 1 [11-371]
Synonyms:
ANM1_HUMAN | HMT2 | HRMT1L2 | IR1B4 | PRMT1 | Protein arginine N-methyltransferase 1 (PRMT1) | Protein arginine methyltransferase 1 (PRMT1) | Protein-arginine N-methyltransferase 1
Type:
Protein
Mol. Mass.:
41506.52
Organism:
Homo sapiens (Human)
Description:
Q99873[11-371]
Residue:
361
Sequence:
MENFVATLANGMSLQPPLEEVSCGQAESSEKPNAEDMTSKDYYFDSYAHFGIHEEMLKDEVRTLTYRNSMFHNRHLFKDKVVLDVGSGTGILCMFAAKAGARKVIGIECSSISDYAVKIVKANKLDHVVTIIKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVLYARDKWLAPDGLIFPDRATLYVTAIEDRQYKDYKIHWWENVYGFDMSCIKDVAIKEPLVDVVDPKQLVTNACLIKEVDIYTVKVEDLTFTSPFCLQVKRNDYVHALVAYFNIEFTRCHKRTGFSTSPESPYTHWKQTVFYMEDYLTVKTGEEIFGTIGMRPNAKNNRDLDFTIDLDFKGQLCELSCSTDYRMR
  
Inhibitor
Name:
BDBM50130931
Synonyms:
CHEMBL3633188
Type:
Small organic molecule
Emp. Form.:
C22H24N8O4
Mol. Mass.:
464.4772
SMILES:
CC(C)(C)OC(=O)Nc1ccc(Nc2ncnc(Nc3ccc(cc3)C(N)=N)c2[N+]([O-])=O)cc1
Structure:
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