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Target
Kynurenine 3-monooxygenase
Ligand
BDBM50131812
Substrate
n/a
Meas. Tech.
ChEMBL_1526206 (CHEMBL3636891)
IC50
>794±n/a nM
Citation
 Abdel-Magid, AF Kynurenine Monooxygenase (KMO) Inhibitors for the Treatment of Acute Pancreatitis and Neurodegenerative Disorders. ACS Med Chem Lett 6:954-5 (2015) [PubMed]  Article 
Target
Name:
Kynurenine 3-monooxygenase
Synonyms:
KMO | KMO_HUMAN
Type:
PROTEIN
Mol. Mass.:
55831.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1487479
Residue:
486
Sequence:
MDSSVIQRKKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTRGRSINLALSHRGRQALKAVGLEDQIVSQGIPMRARMIHSLSGKKSAIPYGTKSQYILSVSRENLNKDLLTAAEKYPNVKMHFNHRLLKCNPEEGMITVLGSDKVPKDVTCDLIVGCDGAYSTVRSHLMKKPRFDYSQQYIPHGYMELTIPPKNGDYAMEPNYLHIWPRNTFMMIALPNMNKSFTCTLFMPFEEFEKLLTSNDVVDFFQKYFPDAIPLIGEKLLVQDFFLLPAQPMISVKCSSFHFKSHCVLLGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFSNDLSLCLPVFSRLRIPDDHAISDLSMYNYIEMRAHVNSSWFIFQKNMERFLHAIMPSTFIPLYTMVTFSRIRYHEAVQRWHWQKKVINKGLFFLGSLIAISSTYLLIHYMSPRSFLRLRRPWNWIAHFRNTTCFPAKAVDSLEQISNLISR
  
Inhibitor
Name:
BDBM50131812
Synonyms:
CHEMBL3634600
Type:
Small organic molecule
Emp. Form.:
C15H16ClNO5
Mol. Mass.:
325.744
SMILES:
OC(=O)CCn1c2cc(Cl)c(OCC3CCC3)cc2oc1=O
Structure:
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