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Target
Mu-type opioid receptor
Ligand
BDBM50135223
Substrate
n/a
Meas. Tech.
ChEMBL_1546048 (CHEMBL3748891)
Ki
195±n/a nM
Citation
 Schembri, LS; Stoddart, LA; Briddon, SJ; Kellam, B; Canals, M; Graham, B; Scammells, PJ Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting theľ-Opioid Receptor. J Med Chem 58:9754-67 (2015) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50135223
Synonyms:
CHEMBL3747317
Type:
Small organic molecule
Emp. Form.:
C27H39Cl2N3O4
Mol. Mass.:
540.522
SMILES:
Cl.Cl.[H][C@@]12Oc3c4c(C[C@@]5([H])N(C)CC[C@@]14[C@]51C[C@H](C(=O)NCCCCCCN)[C@]2(OC)C=C1)ccc3O |r,wU:3.0,15.12,wD:29.31,18.19,16.35,9.7,c:34,THB:12:11:16:8.6.7,(9.21,-3.11,;6.71,-3.11,;-3.09,.25,;-2.14,.56,;-3.29,2.15,;-2.14,3.7,;-.79,2.91,;.54,3.7,;1.89,2.91,;1.89,1.36,;1.02,1.86,;3.25,.56,;4.02,-.36,;2.66,2.1,;.5,2.12,;-.79,1.36,;.54,.56,;.54,-.96,;-.79,-1.74,;-.78,-3.24,;.26,-3.83,;-2.08,-3.99,;-2.07,-5.49,;-3.37,-6.25,;-3.36,-7.75,;-4.65,-8.5,;-4.65,-10,;-5.94,-10.76,;-5.94,-11.96,;-2.14,-.96,;-1.41,.37,;-2.05,1.38,;-.86,-.7,;-.86,.27,;.54,5.25,;-.79,6.03,;-2.14,5.25,;-3.18,5.85,)|
Structure:
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