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Target
Telomeric repeat-binding factor 2-interacting protein 1
Ligand
BDBM50136305
Substrate
n/a
Meas. Tech.
ChEMBL_1547629 (CHEMBL3755499)
Ki
6200±n/a nM
Citation
 Ran, X; Liu, L; Yang, CY; Lu, J; Chen, Y; Lei, M; Wang, S Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex. J Med Chem 59:328-34 (2016) [PubMed]  Article 
Target
Name:
Telomeric repeat-binding factor 2-interacting protein 1
Synonyms:
DRIP5 | Dopamine receptor-interacting protein 5 | RAP1 | RAP1 homolog | Repressor/activator protein 1 homolog | TE2IP_HUMAN | TERF2-interacting telomeric protein 1 | TERF2IP | TRF2-interacting telomeric protein 1 | hRap1
Type:
PROTEIN
Mol. Mass.:
44229.72
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116704
Residue:
399
Sequence:
MAEAMDLGKDPNGPTHSSTLFVRDDGSSMSFYVRPSPAKRRLSTLILHGGGTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYRLGPASAADTGSEAKPGALAEGAAEPEPQRHAGRIAFTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEEDPEAADSGEPQNKRTPDLPEEEYVKEEIQENEEAVKKMLVEATREFEEVVVDESPPDFEIHITMCDDDPPTPEEDSETQPDEEEEEEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSAFLASGQRADGYPIWSRQDDIDLQKDDEDTREALVKKFGAQNVARRIEFRKK
  
Inhibitor
Name:
BDBM50136305
Synonyms:
CHEMBL3752828
Type:
Small organic molecule
Emp. Form.:
C82H138N22O21S2
Mol. Mass.:
1832.238
SMILES:
CCC(C)C(NC(=O)C(NC(=O)C(NC(C)=O)C(C)O)C(C)O)C(=O)NCC(=O)NC(CCSC)C(=O)NC(CCSC)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC1CCCCn2cc(CC(NC(=O)C(CCCCN)NC(=O)C(Cc3ccccc3)NC(=O)C(C)NC1=O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(N)=O)nn2
Structure:
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