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Target
Protein mono-ADP-ribosyltransferase PARP12
Ligand
BDBM50136772
Substrate
n/a
Meas. Tech.
ChEMBL_1548588 (CHEMBL3757407)
IC50
>10000±n/a nM
Citation
 Haikarainen, T; Waaler, J; Ignatev, A; Nkizinkiko, Y; Venkannagari, H; Obaji, E; Krauss, S; Lehtiö, L Development and structural analysis of adenosine site binding tankyrase inhibitors. Bioorg Med Chem Lett 26:328-33 (2016) [PubMed]  Article 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP12
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 12 | ARTD12 | PAR12_HUMAN | PARP-12 | PARP12 | Poly [ADP-ribose] polymerase 12 | ZC3HDC1 | Zinc finger CCCH domain-containing protein 1
Type:
PROTEIN
Mol. Mass.:
79092.00
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107665
Residue:
701
Sequence:
MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLRQRGRFVVAVRAGGAAAAPERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGACKFLRAGKNCRNSHSLTTEHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYNKGDGPHGSCAFQKQCIKLHICQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSDLVSRLPTIYRNAHDIKNKSSAPSRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQICLYHIRKSCSFQDKCHRVHFHLPYRWQFLDRGKWEDLDNMELIEEAYCNPKIERILCSESASTFHSHCLNFNAMTYGATQARRLSTASSVTKPPHFILTTDWIWYWSDEFGSWQEYGRQGTVHPVTTVSSSDVEKAYLAYCTPGSDGQAATLKFQAGKHNYELDFKAFVQKNLVYGTTKKVCRRPKYVSPQDVTTMQTCNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSEEYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLFHGTSAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLVGEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSIFVIFEKHQVYPEYVIQYTTSSKPSVTPSILLALGSLFSSRQ
  
Inhibitor
Name:
BDBM50136772
Synonyms:
CHEMBL3752492
Type:
Small organic molecule
Emp. Form.:
C25H19ClN4O3
Mol. Mass.:
458.896
SMILES:
COc1ccc(cc1)C(=O)Nc1ccc(cc1)C(=O)N(c1ccncn1)c1ccccc1Cl
Structure:
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