Reaction Details
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Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50137105
Substrate
n/a
Meas. Tech.
ChEMBL_1548830 (CHEMBL3755386)
IC50
84000±n/a nM
Citation
Dixit, VA; Rathi, PC; Bhagat, S; Gohlke, H; Petersen, RK; Kristiansen, K; Chakraborti, AK; Bharatam, PV Design and synthesis of novel Y-shaped barbituric acid derivatives as PPAR¿ activators. Eur J Med Chem 108:423-35 (2016) [PubMed] Article More Info.:
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARγ) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Inhibitor
Name:
BDBM50137105
Synonyms:
CHEMBL3753871
Type:
Small organic molecule
Emp. Form.:
C28H28N4O6
Mol. Mass.:
516.5451
SMILES:
[#6]-[#8]-c1ccc(-[#6]-[#8]-[#6]-[#6]-[#7](-[#6]-[#6]-[#8]-c2ccccn2)-c2ccc(\[#6]=[#6]-3/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-3=O)cc2)cc1
Structure:
