Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50137655
Substrate
n/a
Meas. Tech.
ChEMBL_1549482 (CHEMBL3755808)
Ki
6918±n/a nM
Citation
 Hammer, SG; Gobleder, S; Naporra, F; Wittmann, HJ; Elz, S; Heinrich, MR; Strasser, A 2,4-Diaminopyrimidines as dual ligands at the histamine H1 and H4 receptor-H1/H4-receptor selectivity. Bioorg Med Chem Lett 26:292-300 (2016) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50137655
Synonyms:
CHEMBL3752270
Type:
Small organic molecule
Emp. Form.:
C24H27N5
Mol. Mass.:
385.5047
SMILES:
CN1CCN(CC1)c1nc(NCc2ccccc2)nc-2c1CCc1ccccc-21
Structure:
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