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Target
Plasminogen
Ligand
BDBM50138884
Substrate
n/a
Meas. Tech.
ChEMBL_1549971 (CHEMBL3755269)
IC50
1600±n/a nM
Citation
 Hidaka, K; Gohda, K; Teno, N; Wanaka, K; Tsuda, Y Active site-directed plasmin inhibitors: Extension on the P2 residue. Bioorg Med Chem 24:545-53 (2016) [PubMed]  Article 
Target
Name:
Plasminogen
Synonyms:
Activation peptide | Angiostatin | PLG | PLMN_HUMAN | Plasmin | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B
Type:
Enzyme
Mol. Mass.:
90579.18
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
810
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFTCRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN
  
Inhibitor
Name:
BDBM50138884
Synonyms:
CHEMBL3754642
Type:
Small organic molecule
Emp. Form.:
C36H49N3O3
Mol. Mass.:
571.7926
SMILES:
CCCCCCCCNC(=O)[C@H](Cc1ccc(OCc2cccc3ccccc23)cc1)NC(=O)[C@H]1CC[C@H](CN)CC1 |r,wU:34.36,11.11,wD:37.40,(5.29,.53,;5.3,-.7,;3.97,-1.48,;3.99,-3.02,;2.66,-3.8,;2.67,-5.35,;1.35,-6.13,;1.36,-7.67,;.03,-8.45,;.05,-9.99,;1.12,-10.6,;-1.28,-10.78,;-2.62,-10.02,;-2.63,-8.48,;-3.97,-7.71,;-3.98,-6.17,;-2.65,-5.4,;-2.66,-3.85,;-1.33,-3.08,;-1.33,-1.54,;-2.68,-.77,;-2.68,.77,;-1.33,1.54,;,.77,;1.33,1.54,;2.66,.77,;2.66,-.77,;1.33,-1.54,;,-.77,;-1.31,-6.16,;-1.3,-7.7,;-1.27,-12.32,;.07,-13.08,;1.13,-12.45,;.09,-14.62,;1.42,-15.38,;1.43,-16.92,;.1,-17.7,;.12,-19.24,;1.19,-19.85,;-1.24,-16.94,;-1.24,-15.4,)|
Structure:
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