Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50138169
Substrate
n/a
Meas. Tech.
ChEMBL_1549645 (CHEMBL3756705)
EC50
22000±n/a nM
Citation
 Ma, Z; Lin, DC; Sharma, R; Liu, J; Zhu, L; Li, AR; Kohn, T; Wang, Y; Liu, JJ; Bartberger, MD; Medina, JC; Zhuang, R; Li, F; Zhang, J; Luo, J; Wong, S; Tonn, GR; Houze, JB Discovery of the imidazole-derived GPR40 agonist AM-3189. Bioorg Med Chem Lett 26:15-20 (2015) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50138169
Synonyms:
CHEMBL3754682
Type:
Small organic molecule
Emp. Form.:
C27H25ClN2O3
Mol. Mass.:
460.952
SMILES:
Cc1c(Cl)cccc1-c1cccc(COc2ccc(cc2)[C@H](CC(O)=O)c2nccn2C)c1 |r|
Structure:
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