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Target
Melanocortin receptor 4
Ligand
BDBM50019939
Substrate
n/a
Meas. Tech.
ChEMBL_1549671 (CHEMBL3756897)
EC50
640±n/a nM
Citation
 Ma, Z; Lin, DC; Sharma, R; Liu, J; Zhu, L; Li, AR; Kohn, T; Wang, Y; Liu, JJ; Bartberger, MD; Medina, JC; Zhuang, R; Li, F; Zhang, J; Luo, J; Wong, S; Tonn, GR; Houze, JB Discovery of the imidazole-derived GPR40 agonist AM-3189. Bioorg Med Chem Lett 26:15-20 (2015) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R_RAT | Mc4r
Type:
PROTEIN
Mol. Mass.:
36892.87
Organism:
Rattus norvegicus
Description:
ChEMBL_11005
Residue:
332
Sequence:
MNSTHHHGMYTSLHLWNRSSHGLHGNASESLGKGHSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVRRVGIIISCIWAACTVSGVLFIIYSDSSAVIICLITMFFTMLVLMASLYVHMFLMARLHIKRIAVLPGTGTIRQGANMKGAITLTILIGVFVVCWAPFFLHLLFYISCPQNPYCVCFMSHFNLYLILIMCNAVIDPLIYALRSQELRKTFKEIICFYPLGGICELPGRY
  
Inhibitor
Name:
BDBM50019939
Synonyms:
CHEMBL3287569
Type:
Small organic molecule
Emp. Form.:
C27H25ClN2O3
Mol. Mass.:
460.952
SMILES:
Cc1cc(Cl)ccc1-c1cccc(COc2ccc(cc2)[C@H](CC(O)=O)c2nccn2C)c1 |r|
Structure:
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