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Target
Mitochondrial sodium/calcium exchanger protein
Ligand
BDBM50139422
Substrate
n/a
Meas. Tech.
ChEBML_1553171
IC50
1600±n/a nM
Citation
 Martínez-Sanz, FJ; Lajarín-Cuesta, R; González-Lafuente, L; Moreno-Ortega, AJ; Punzón, E; Cano-Abad, MF; de los Ríos, C Neuroprotective profile of pyridothiazepines with blocking activity of the mitochondrial Na(+)/Ca(2+) exchanger. Eur J Med Chem 109:114-23 (2016) [PubMed]  Article 
Target
Name:
Mitochondrial sodium/calcium exchanger protein
Synonyms:
NCKX6 | NCKX6 | NCLX | NCLX_HUMAN | Na(+)/K(+)/Ca(2+)-exchange protein 6 | SLC24A6 | SLC8B1 | Sodium/calcium exchanger protein, mitochondrial | Sodium/potassium/calcium exchanger 6, mitochondrial | Solute carrier family 24 member 6 | Solute carrier family 8 member B1
Type:
PROTEIN
Mol. Mass.:
64239.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116727
Residue:
584
Sequence:
MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
  
Inhibitor
Name:
BDBM50139422
Synonyms:
CHEMBL1495071
Type:
Small organic molecule
Emp. Form.:
C15H11Cl2NOS
Mol. Mass.:
324.225
SMILES:
Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1
Structure:
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