Reaction Details Report a problem with these data
Target
Transmembrane domain-containing protein TMIGD3
Ligand
BDBM50118803
Substrate
n/a
Meas. Tech.
ChEMBL_1556380 (CHEMBL3772111)
IC50
42±n/a nM
Citation
 Donegan, RK; Lieberman, RL Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions. J Med Chem 59:788-809 (2016) [PubMed]  Article 
Target
Name:
Transmembrane domain-containing protein TMIGD3
Synonyms:
TMIG3_HUMAN | TMIGD3 | Transmembrane domain-containing protein TMIGD3
Type:
PROTEIN
Mol. Mass.:
30335.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_114868
Residue:
266
Sequence:
MEGSPAGPIEQKEARWESSWEEQPDWTLGCLSPESQFRIPGLPGCILSFQLKVCFLPVMWLFILLSLALISDAMVMDEKVKRSFVLDTASAICNYNAHYKNHPKYWCRGYFRDYCNIIAFSPNSTNHVALRDTGNQLIVTMSCLTKEDTGWYWCGIQRDFARDDMDFTELIVTDDKGTLANDFWSGKDLSGNKTRSCKAPKVVRKADRSRTSILIICILITGLGIISVISHLTKRRRSQRNRRVGNTLKPFSRVLTPKEMAPTEQM
  
Inhibitor
Name:
BDBM50118803
Synonyms:
(2R,3R,4S,5S)-3,4-dihydroxy-2-[6-(3-iodo-benzylamino)-purin-9-yl]-1-oxa-7-aza-spiro[4.4]nonan-6-one | 3,4-Dihydroxy-2-[6-(3-iodo-benzylamino)-purin-9-yl]-1-oxa-7-aza-spiro[4.4]nonan-6-one | CHEMBL344187
Type:
Small organic molecule
Emp. Form.:
C19H19IN6O4
Mol. Mass.:
522.2964
SMILES:
O[C@@H]1[C@H](O)[C@]2(CCNC2=O)O[C@H]1n1cnc2c(NCc3cccc(I)c3)ncnc12
Structure:
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