Reaction Details
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dCTP pyrophosphatase 1
Ligand
BDBM50150112
Substrate
n/a
Meas. Tech.
ChEMBL_1558383 (CHEMBL3772975)
IC50
27±n/a nM
Citation
Llona-Minguez, S; Höglund, A; Jacques, SA; Johansson, L; Calderón-Montaño, JM; Claesson, M; Loseva, O; Valerie, NC; Lundbäck, T; Piedrafita, J; Maga, G; Crespan, E; Meijer, L; Burgos Morón, E; Baranczewski, P; Hagbjörk, AL; Svensson, R; Wiita, E; Almlöf, I; Visnes, T; Jeppsson, F; Sigmundsson, K; Jensen, AJ; Artursson, P; Jemth, AS; Stenmark, P; Warpman Berglund, U; Scobie, M; Helleday, T Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. J Med Chem 59:1140-8 (2016) [PubMed] Article More Info.:
Target
Name:
dCTP pyrophosphatase 1
Synonyms:
DCTP1_HUMAN | DCTPP1 | Deoxycytidine-triphosphatase 1 | XTP3TPA | dCTP pyrophosphatase 1 | dCTP pyrophosphatase 1 (DCTPP1)
Type:
Protein
Mol. Mass.:
18673.58
Organism:
Homo sapiens (Human)
Description:
Q9H773
Residue:
170
Sequence:
MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
Inhibitor
Name:
BDBM50150112
Synonyms:
CHEMBL3769835
Type:
Small organic molecule
Emp. Form.:
C17H14BCl2N3O4
Mol. Mass.:
406.028
SMILES:
OB(O)c1ccc(Cn2c(nc3c(c(Cl)c(Cl)cc23)[N+]([O-])=O)C2CC2)cc1
Structure:
