Reaction Details Report a problem with these data
Target
Kallikrein-5 [D153N]
Ligand
BDBM50154253
Substrate
n/a
Meas. Tech.
ChEMBL_1560427 (CHEMBL3776088)
Ki
130±n/a nM
Citation
 Hoelz, LV; Zorzanelli, BC; Azevedo, PH; Passos, SG; de Souza, LR; Zani, M; Pinheiro, S; Puzer, L; Dias, LR; Muri, EM Synthesis, biological evaluation and molecular modeling of pseudo-peptides based statine as inhibitors for human tissue kallikrein 5. Eur J Med Chem 112:39-47 (2016) [PubMed]  Article 
Target
Name:
Kallikrein-5 [D153N]
Synonyms:
KLK-L2 | KLK5 | KLK5_HUMAN | Kallikrein 5 | Kallikrein-5 | Kallikrein-like protein 2 | SCTE | Stratum corneum tryptic enzyme
Type:
PROTEIN
Mol. Mass.:
32031.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1282456
Residue:
293
Sequence:
MATARPPWMWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKKVFRVRLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNNLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLVSGWGTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPRQIDDTMFCAGDKAGRDSCQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQANS
  
Inhibitor
Name:
BDBM50154253
Synonyms:
CHEMBL3775377
Type:
Small organic molecule
Emp. Form.:
C22H34N2O6
Mol. Mass.:
422.5152
SMILES:
COC(=O)[C@@H](NC(=O)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(C)C |r|
Structure:
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