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Target
Dual specificity protein kinase CLK4
Ligand
BDBM50154342
Substrate
n/a
Meas. Tech.
ChEMBL_1560211 (CHEMBL3778450)
IC50
18±n/a nM
Citation
 Mariano, M; Hartmann, RW; Engel, M Systematic diversification of benzylidene heterocycles yields novel inhibitor scaffolds selective for Dyrk1A, Clk1 and CK2. Eur J Med Chem 112:209-16 (2016) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK4
Synonyms:
CDC-like kinase 4 | CLK4 | CLK4_HUMAN | Dual specificity protein kinase CLK1/CLK4
Type:
Serine/threonine-protein kinase
Mol. Mass.:
57522.53
Organism:
Homo sapiens (Human)
Description:
gi_10190706
Residue:
481
Sequence:
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK
  
Inhibitor
Name:
BDBM50154342
Synonyms:
CHEMBL3774448
Type:
Small organic molecule
Emp. Form.:
C13H8N2OS2
Mol. Mass.:
272.345
SMILES:
O=C1NC(=S)S\C1=C/c1ccc2ncccc2c1
Structure:
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